C-reactive Protein, Urea, Creatinin and Total Protein Concentrations in Canine Leishmaniasis

Abstract

In the present study, we aimed to investigate the serum levels of CRP, urea, creatinin and total protein so as to support the diagnosis detect the severity of illness monitor the post-therapy period. Our study was performed in Kusadasi town belonging to Aydin city and two villages of Denizli city which are endemic regions for CanL. A total of 60 dogs have been included, 38 parasitologically and/or serologically proven CanL cases and 22 healthy dogs for control, to our study. The serum levels of CRP, urea, creatinin and total protein of each dog were measured. The average value of urea and creatinin was detected to be higher when compared with control sera [urea; patient 52,95 ? 38,73 mg/dL, control, 35,68 ? 11,40 mg/dL (p<0,05); creatinin; patient 1,01 ? 0,36 mg/dL, control 0,66 ? 0,30 mg/dL(p<0,001)]. The difference between two groups was statistically important. These findings show that the measurement of serum levels of urea and creatinin is useful to detect kidney failure in CanL cases. The average value of total protein was detected to be higher in CanL cases when compared with the control group (patients group; 10,34 ? 1,90 g/L, and control group 7,87 ? 1,15 g/L). The difference between two groups was statistically important (p< 0,0001). This increase is an important parameter for the prognosis of the disease, and depends on the increase of circulating immunoglobulins in the blood of the patients. The serum levels of CRP were found to be icreased in CanL cases when compared with the control group (patients; 45.36 ? 33.05 µg/dL, control; 8.03?4.34 µg/dL). The difference between two groups was statistically important (p<0,0001). All these findings show that serum CRP, urea and creatinin parameters can be used as an indicator for the diagnosis of canine visceral leishmaniasis.