The Effect of Combined Treatment with Mentha longifolia L. and Docetaxel on Drug Resistance in Colon Cancer


Abstract views: 41 / PDF downloads: 54

Authors

DOI:

https://doi.org/10.5281/zenodo.12167759

Keywords:

Mentha longifolia L, colon cancer, drug resistance

Abstract

This study investigates the effects of Mentha longifolia L. and the chemotherapeutic drug docetaxel on drug resistance in colon cancer. One of the major challenges in colon cancer treatment is the resistance of cancer cells to chemotherapy drugs. The primary mechanism of this resistance involves the overexpression of multi-drug resistance (MDR/ABCB1) genes. MDR genes reduce the intracellular accumulation of chemotherapeutic agents in cancer cells. The study examined the effects of Mentha longifolia L. extract and docetaxel on ABCB1 gene expression in the HT-29 colon cancer cell line. HT-29 cells were cultured in RPMI medium and CCD18-Co cells in MEM medium, both containing 10 % fetal bovine serum (FBS), penicillin (100 U mL-1), and streptomycin (10 mg L-1), at 37 °C, 5 % CO2, and 95 % humidity. Results showed that Mentha longifolia L. extract alone did not significantly alter ABCB1 gene expression, but in combination with docetaxel, it significantly increased gene expression. This finding suggests that Mentha longifolia L. could play a potentially important role in overcoming drug resistance in cancer cells by enhancing the efficacy of docetaxel.

References

Aksoy, Y., 2011. Ways to overcome drug resistance in cancer: Designing new drugs, Journal of Medical Sciences, 30(6).

Alkan, M., Güzel, M., Akşit, H., Bağdat, R.B., Alkan, F.R., Evlice, E., 2021. Chemical components and insecticidal effects of essential oils from three lavender cultivars against adult Sitophilus granarius (L., 1758) (Coleoptera: Curculionidae). Turkish Journal of Entomology, 45(4): 405-416.

Anonim, 2023. "Mentha longifolia (L.) L. | Plants of the World Online | Kew Science". Plants of the World Online. Retrieved 11-14.

Anonim, 2024. Turkish medical oncology association. (https://www.kanser.org/saglik/toplum/kanser- tarama/ulkemizde-kanser-tarama-programlari), (Erişim Tarihi: 16.02.2024)

Bayık, A., 1989. Cancer epidemiology, Journal of Ege University Faculty of Nursing, 5(3): 58-71.

Beheshtian, N., Karimi, E., Asili, J., Beheshtin, N., Le, H.H., Shakeri, M., 2023. Mentha longifolia L. inhibits colorectal cancer cell proliferation and induces apoptosis via caspase regulation. International Journal of Translational Medicine, 3(4): 416-425.

Brinkmann, U., Eichelbaum, M., 2001. Polymorphisms in the ABC drugtransporter gene MDR1. The Phanmacogenomics Journal, 1: 59-64.

Chakraborty, R., Gupta, H., Rahman, R., Hasija, Y., 2018. In silico analysis of nsSNPs in ABCB1 gene affecting breast cancer associated protein P-glycoprotein (P-gp). Computational Biology and Chemistry, 77: 430-441.

Diane, L., McKay Jeffrey, B., Blumberg, A., 2006. Review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.), Wiley Inter Science, 619-633.

Durusoy, Ç., Ulusal, B.G., 2007. Herbal therapy in dermatology-phytotherapy. Turkish Journal of Dermatology, 1: 47-50.

Green, R.J., 1963. MintFarming, Agriculture Information Bulletin No. 212. U.S. Department of Agriculture, Washington, DC, p. 26.

Jamroziak, K., Robak, T., 2004. Pharmacogenomics of MDR1/ABCB1 gene the influence on risk and clinical outcome of haematological malignancies, Hematology, 9(2): 91-105.

Kurhan, İ., Ekici, H., 2021. Complementary- phytotherapy and cancer approach under traditional medicine, Bulletin of Veterinary Pharmacology and Toxicology Association, 12(1): 15-20.

Lange, B.M., Croteau, R., 1999. Genetic engineering of essential oil production in mint. Current Opinion in Plant Biology, 2(2): 139-144.

Liu, W., Lawrence, B.M., 2007. Production of mintsandmintoil in China. In: Lawrence, B.M. (Ed.), Mint: GenusMentha. Taylor & Francis Group, Boca Raton, FL, pp. 165-184.

Mucciarelli, M., Camusso, W., Bertea, C. M., Bossi, S., Maffei, M., 2001. Effect of (+)-pulegone and other oil components of Mentha × piperita on cucumber respiration. Phytochemistry, 57(1): 91-98.

Remzi, F.H., Öncel, M., 2006. Screening and Surveillance for Colorectal Cancer, 17(1): 50-57.

Şen, S.K., Öztürk, Y.K., 2020. Relationship between health perception and cancer screening awareness, Turkish Journal of Family Practice, 24(4): 175-183.

Seyfried, T.N., Huysentruyt, L.C., 2013. On the origin of cancer metastasis, Critical Reviews in Oncogenesis, 18(12): 43-73.

Talhaoğlu, D., 2021. Traditional and complementary treatment practices. Journal of Integravite and Anatolian Medicine, 3(1): 16-29.

Tekpınar, H., Aşık, Z., Özen, M., 2018. Evaluation of the approaches of patients who applied to the Family Medicine outpatient clinic regarding cancer screenings. 22(1): 28-36.

Ünal, M., Dağdeviren, H.N., 2019. Traditional and Complementary Medicine Methods, Eurasian Journal of Family Medicine, 8(1): 1-9.

Valaes, T., 1994. Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency: pathogenesis and global epidemiology. Acta Paediatrica, 83: 58-76.

Wang, F., Li, D., Zheng, Z., Kin Wah To, K., Chen, Z., Zhong, M., Fu, L., 2020. Reversal of ABCB1-related multidrug resistance by ERK5-IN-1. Journal of Experimental & Clinical Cancer Research, 39: 1-13.

White, A., Thompson, T.D., White, M.C., Sabatino, S.A., Moor, J., Paul, V., Doria- Rose, Geiger, A.M., Richardson, L.C., 2015. Cancer Screening Test Use- United States, MMWR.

WHO, 2000. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine, WHO/EDM/TRM/2000.1

Downloads

Published

2024-06-19

How to Cite

AHMEDLİ , D., GÜMÜŞ, Z., YETKİN , R., KABAK , G., & SİLİĞ , Y. (2024). The Effect of Combined Treatment with Mentha longifolia L. and Docetaxel on Drug Resistance in Colon Cancer. MAS Journal of Applied Sciences, 9(2), 459–465. https://doi.org/10.5281/zenodo.12167759

Issue

Section

Articles

Most read articles by the same author(s)