Investigation of the Effect of Allium polyanthum on the ABCB1 Gene in Colon Cancer Treatment
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https://doi.org/10.5281/zenodo.12167176Keywords:
Allium polyanthum, colorectal cancer, drug resistanceAbstract
Colorectal cancer is one of the most common cancer types worldwide, presenting various challenges in treatment processes. This study investigates the potential effects of Allium polyanthum in colon cancer treatment, particularly focusing on its impact on the ABCB1 gene. The ABCB1 gene plays a significant role in developing resistance to chemotherapy drugs in cancer cells. In this research, in vitro colon cancer cell lines were utilized to examine the effects of Allium polyanthum extract on ABCB1 gene expression. Another crucial component of the study involves the evaluation of docetaxel, a commonly used chemotherapy drug in colon cancer treatment. Docetaxel belongs to the taxane class of drugs, effectively halting the division of cancer cells, but resistance development can limit treatment success. The results demonstrate that Allium polyanthum extract enhances docetaxel efficacy in colon cancer cells by suppressing ABCB1 gene expression.
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