Investigation of the Effect of Allium polyanthum on the ABCB1 Gene in Colon Cancer Treatment


Abstract views: 34 / PDF downloads: 26

Authors

DOI:

https://doi.org/10.5281/zenodo.12167176

Keywords:

Allium polyanthum, colorectal cancer, drug resistance

Abstract

Colorectal cancer is one of the most common cancer types worldwide, presenting various challenges in treatment processes. This study investigates the potential effects of Allium polyanthum in colon cancer treatment, particularly focusing on its impact on the ABCB1 gene. The ABCB1 gene plays a significant role in developing resistance to chemotherapy drugs in cancer cells. In this research, in vitro colon cancer cell lines were utilized to examine the effects of Allium polyanthum extract on ABCB1 gene expression. Another crucial component of the study involves the evaluation of docetaxel, a commonly used chemotherapy drug in colon cancer treatment. Docetaxel belongs to the taxane class of drugs, effectively halting the division of cancer cells, but resistance development can limit treatment success. The results demonstrate that Allium polyanthum extract enhances docetaxel efficacy in colon cancer cells by suppressing ABCB1 gene expression.

References

Akay, G.G., 2010. MDR1 Gene Single Nucleotide Polymorphisms in Cancer Pharmacogenetics. Journal of Medical Sciences, 30: 29-36.

Alam, K., Hoq, O., Uddin, S., 2016. Medicinal plant Allium sativum. A review. Journal of Medicinal Plant Studies, 4(6): 72-79.

Alkan, M., Güzel, M., Akşit, H., Bağdat, R.B., Alkan, F.R., Evlice, E., 2021. Chemical components and insecticidal effects of essential oils from three lavender cultivars against adult Sitophilus granarius (L. 1758) (Coleoptera: Curculionidae). Turkish Journal of Entomology, 45(4): 405-416.

Ameen, M., Musthapa, M.S., Abidi, P., Ahmad, I., Rahman, Q., 2003. Garlic attenuates chrysotile- mediated pulmonary toxicity in rats by altering the phase I and phase II drug metabolizing enzyme system. Journal of Biochemical and Molecular Toxicology, 17: 366–71.

Anonim, 2024. (https://en.wikipedia.org/wiki/Allium_polyanthum), (Erişim Tarihi: 10.04.2024)

Bose, S., Laha, B., Banerjee, S., 2014. Quantification of allicin by high performance liquid chromatography-ultraviolet analysis with effect of post-ultrasonic sound and microwave radiation on fresh garlic cloves. Pharmacognosy Magazine, 10: 288-293.

Deniz, E.A., 2022. Cancer epidemiology, SOYD, 3(2): 102-111

Diretto, G., Rubio-Moraga, A., Argandona, J., Castillo, P., Gomez-Gomez, L., Ahrazem, O., 2017. Tissue-specific accumulation of sulfur compounds and saponins in different parts of garlic cloves from purple and white ecotypes. Molecules, 22: 1359.

Engle, K., Kumar, G., 2022. Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update. European Journal of Medicinal Chemistry, 239: 114542.

Erdemoğlu, N., Şener, B., 2000. Taksan sınıfı bileşiklerin antitümör etkileri. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 29(1): 77-90.

Gürbüz, V., Yılmaz, A., Gökçe, Ö., Konaç, E., 2015. İnsan kolon kanser hücre hattında (HT29) Sisplatin’in apoptotik etkisi, Marmara Medical Journal, 24(2): 100-105.

Lawson, L.D., Ransom, D.K., Hughes, B.G., 1992. Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products. Thrombosis Research, 65: 141–56.

Leiri, I., 2012. The MDR1(ABCB1) gene polymorphism and its clinical implication. Clinical Pharmacokinetics, 43: 553-576

Londhe, V.P., Gavasane, A.T., Nipate, S.S., Bandawane, D.D., Chaudhari, P.D., 2011. Role of garlic (Allium sativum) in various diseases: An overview. Angiogenesis, 12(13): 129-134.

Marre, F., Sanderink, G., de Sousa, G., Gaillard, C., Martinet, M., Rahmani, R., 1996. Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans. Cancer Research, 56: 1296–302.

Marzolini, C., Paus, E., Buclin, T., Kim, R.B., 2004. Polymorphisms in Human MDR1 (P- glycoprotein): Recent Advances and Clinical Relevance, Clinical Pharmacology & Therapeutics, 75(1): 13-33.

Remzi, F.H., Öncel, M., 2006. Kolon kanserinde tarama ve takip. 6. Koloproktoloji Sempozyumu, 14-16 Nisan, Adana.

Seckiner, I., Bayrak, O., Can, M., Mungan, A.G., Mungan, N.A., 2014. Garlic supplemented diet attenuates gentamicin nephrotoxicity in rats. International Brazilian Journal of Urology, 40: 562-567.

Shang, A., Cao, S.Y., Xu, X.Y., Gan, R.Y., Tang, G.Y., Corke, H., Mavumengwana, V., Li, H.B., 2019. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods, 8(7): 246.

Singh, V.K., Singh, D.K., 2008. Pharmacological effects of garlic (Allium sativum L.). ARBS Annual Review of Biomedical Sciences, 10: 6-26.

Szychowski, K.A., Rybczynska-Tkaczyk, K., Gawel-Beben, K., Swieca, M., Karas, M., Jakubczyk, A., Matysiak, M., Binduga, U.E., Gminski, J., 2018. Characterization of active compounds of different garlic (Allium sativum L.) cultivars. Polish Journal of Food and Nutrition Sciences, 68: 73-81.

Wang, Y.J., Huang, Y., Anreddy, N., Zhang, G.N., Zhang, Y.K., Xie, M., Chen, Z.S., 2016. Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin. Oncotarget, 7(5): 5877.

Yun, H.M., Ban, J.O., Park, K.R., Lee, C.K., Jeong, H.S., Han, S.B., Hong, J.T., 2014. Potential therapeutic effects of functionally active compounds isolated from garlic. Pharmacology & Therapeutics, 142: 183-195.

Downloads

Published

2024-06-19

How to Cite

KÖKTEN, F., ŞAHİN , F. B., KEŞAN , H., KABAK , G., & SİLİĞ , Y. (2024). Investigation of the Effect of Allium polyanthum on the ABCB1 Gene in Colon Cancer Treatment. MAS Journal of Applied Sciences, 9(2), 437–443. https://doi.org/10.5281/zenodo.12167176

Issue

Section

Articles

Most read articles by the same author(s)