History of Nonsteroidal Anti-inflammatory Hypersensitivity and Gastromucosal Evaluation; Cross-Sectional Study

Abstract

There is limited research evaluating gastrohistopathologic findings in individuals with a history of Nonsteroidal Anti-inflammatory Drug (NSAID) Hypersensitivity. In this study, we aimed to evaluate the biochemical parameters and endoscopic findings of individuals with a history of NSAID hypersensitivity. Patients with a history of NSAID hypersensitivity and those without a history of NSAID hypersensitivity were retrospectively divided into two groups from the file records of individuals who applied to the gastroenterology outpatient clinic and underwent endoscopy. Data on endoscopy results, Helicobacter pylori(H.pylori), metaplasia, atrophy and biochemical results were evaluated.The mean age of the participants was 57.20 ± 16.27 years. H.pylori positivity in the gastrohistopathology of individuals with NSAID allergy was 61.50% (n=16) and 24.40% in the control group (n=10). H.pylori negativity was 75.60% in the group without NSAID allergy (n=31) and 38.50% in the group with allergy (n=10). H. pylori positivity in the group with NSAID allergy was statistically significant compared to the control group (p=0.002). Considering the public health importance of NSAID allergy, this review provides an evaluation in terms of metaplasia, atrophy and H.pylori.