An Investigation On The Correlation Between Oxidative Stress And Cognitive Functions In Patients With Euthymic Bipolar Disorder

Abstract

Objective: To investigate the relationship between oxidative stress and cognitive functions in bipolar patients. Methods:The sample of the study consisted of 50 patients and 50 healthy volunteers who applied to the Department of Psychiatry. Global Clinical Monitoring Scale (GCMS), Hamilton Depression Scale (HAM-D), Young Mania Rating Scale (YMRS), serial step learning test (SDLT), Stroop Test Basic Sciences Research Group Form (ST-TBAG), Preliminary Evaluation Battery ( ST-TBAG) FAB) was applied to healthy volunteers with a socio-demographic data form. In addition, venous blood was collected and Total Oxidant Level (TOL) and Total Antioxidant Level (TAL) were measured. Results:TOL and OSI levels were found to be significant between the patient groups and the control group in the tests and measurements performed (p <0.01). The stroop test applied to both the patient and the control group was statistically significant in terms of Frontal Assessment Battery (FAB) and number series learning test (p <0.05). In addition, there was a statistically significant relationship between FAB and TOL (p: 0.012 r: -0.353) and OSI (p: 0.014 r: -0.346) applied to patients. Conclusion: As a result, there was a significant correlation with oxidative parameters and disorder in cognitive function tests compared to the control group.