Evaluation of Folate and Vitamin B12 Levels in Psychiatric Patients in Şırnak Region

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Biochemistry, psychiatry, B12, folate


The most severe and prevalent type of neuropsychiatric condition, which affects millions of people globally, is major depressive disorder. Our study's objective is to assess the levels of folate and vitamin B12 in outpatient mental patients in the province of Şırnak. The patients who applied to the Psychiatric Services of the state hospitals in the Şırnak region between January 1, 2021, and January 5, 2022 were found by conducting a retrospective search of the hospital databases for folate and vitamin B12 levels. Device reference ranges between 200-771 pg mL-1 were accepted for the evaluation of vitamin B12 levels and 4.6-18.7 ng mL-1 for the evaluation of folate levels. 9.6% of the males and 13.7% of the women who applied to the psychiatry service in Şırnak during the study period had B12 levels below 200 pg mL-1, whereas 86.5% of the men and 84.3% of the women had B12 levels between 200 and 771 pg mL-1. It was found that 3.8% of men and 2% of women were above 771 pg mL-1. It was found that there was no significant difference in the statistical analysis results according to gender (P>0.05). In folate levels, 56.3% of male patients and 42.9% of females had folate levels below 4.6 ng mL-1, while 43.7% of men and 50% of women had folate levels between 4.6-18.7 ng mL-1. found. It was observed that there was no statistically significant difference in the folate levels of the patients according to gender (P>0.05). In our research, we were unable to find any evidence that the rate of vitamin B12 insufficiency is higher in psychiatric patients. Although the folate level was not statistically significant, it was found to be significant as a percentage. By changing serum levels of folate and vitamin B12, dietary habits may be linked to depression.





Abou-Saleh, M.T., Coppen, A. 2006. Folic acid and the treatment of the depression. Journal of Psychosomatic Research 61: 285-287.

Acarkan, T., Nazlıkul, H. 2017. Depresyona tamamlayıcı tıp yaklaşımı. Journal of Complementary Medicine, Regulation and Neural Therapy 11: 20-23.

Atadağ, Y., Aydın, A., Köşker, H.D. 2017.Vitamin B12 ve depresyon-aksiyete bozuklukları ilişkisi: Retrospektif kohort çalışma. Arch Clin Exp Med. 2:6-8.

Baytan, B., Özdemir, Ö., Erdemir, G. 2007. Çocukluk çağında vitamin B12 eksikliği klinik bulgular ve tedavi. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 33(2): 61-64.

Borradale, D., Isenring, E., Hacker, E. 2014. Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age. J Photochem Photobiol B. 131:90-95.

Demirkol, M.E., Tamam, L., Çakmak, S. 2019. Şizofreni tanılı hastalarda metabolik sendrom ve D vitamini düzeyleri ilişkisi. Cukurova Medical Journal 44:1110-1117

Dudek, K.A., Dion-Albert, L., Kaufmann, F.N. 2021. Neurobiology of resilience in depression: immune and vascular insights from human and animal studies. Eur J Neurosci. 53:183-221.

Gazzali, A.M., Lobry, M., Colombeau, L. 2016. Stability of folic acid under several parameters. Eur J Pharm Sci. 93:419-430.

Hintikka, J., Tolmunen, T., Tanskanen, A. 2003. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder. BMC Psychiatry 3: 17.

Kar, F., Hacıoğlu, C., Küskü Kiraz, Z. 2018.Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi. TJLS. 3: 210-213.

Karadima, V., Kraniotou, C., Bellos, G. 2016. Drug-micronutrient interactions: food for thought and thought for action. EPMA J. 7(1):10.

Khosravi, M., Sotoudeh, G., Amini, M. 2020.The relationship between dietary patterns and depression mediated by serum levels of Folate and vitamin B12. BMC Psychiatry. 20:63.

Lee, S., Wing, Y.K., Fong, S. 1998. A controlled study of folate levels in Chinese inpatients with major depression in Hong Kong. J Affect Diosord, 49:73-77

Lerner, V., Kanevsky, M., Dwolatzky, T. 2006. Vitamin B12 and folat serum levels in newly admitted psychiatric patients. Clinical Nutrition 25:60-67.

Moretti, R., Giuffré, M., Caruso, P. 2021. Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease. Int J Mol Sci. 22: 2051.

Okereke, O.I., Cook, N.R., Albert, C.M. 2015. Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women. Br J Psychiatry 206: 324-331.

Romain, M., Sviri, S., Linton, D.M. 2016. The role of Vitamin B12 in the critically ill--a review. Anaesth Intensive Care. 44: 447-452.

Vorobei, A.V., Vorobei, P.A. 2011. Photosensitized degradation of folic acid J. Appl. Spectrosc., 78:614-616

Yener, G., Van Loon, P. 2009. Vitamin B12 status in patients of Turkish and dutch descent with depression: a comparative cross-sectional study. Ann General Psychiatry 8: 18.




How to Cite

TAHİROĞLU, V., ALAYUNT, N. Ömer, COŞKUN, E., & APA, F. (2022). Evaluation of Folate and Vitamin B12 Levels in Psychiatric Patients in Şırnak Region. MAS Journal of Applied Sciences, 7(4), 847–854. https://doi.org/10.5281/zenodo.7161765