Assessment of Lipid Profile, Paraoxonase 1 (PON1) and Arylesterase Activities in Healthy Individuals with Different Blood Types

Abstract

Our aim in this study is to determine whether there is a relationship between ABO/Rh blood groups and paraoxonase/Arylesterase enzyme activities and lipid levels which play an important role in the development of atherosclerosis. Eight different blood groups were taken regarding to ABO and Rh blood group system. Each group consisted of 20 participants. Serum paraoxonase and arylesterase activities were measured spectrophotometrically. Serum total cholesterol, triglyceride, LDL, HDL and VLDL cholesterol levels were measured by the colorimetric methods in a biochemical autoanalyzer. ABO blood groups when compared in terms of paraoxonase enzyme activity, in O blood group it was significantly higher than those of the A and B blood groups (p:0.036), In O blood group arylesterase enzyme activities were significantly higher than that of the AB blood group (p:0.021). There was not significant difference found in terms of LDL cholesterol and Total cholesterol levels among the all blood groups. In AB blood group HDLcholesterol levels were significantly lower than that of the blood group A (p:0,020). When Rh blood groups were compared in terms of lipid parameters and Arylesterase/Paraoxonase enzyme activities, Rh- blood group was found to have significantly higher levels of Triglyceride and VLDL cholesterol levels than Rh+ blood group (p<0.05). In blood group O, significantly higher paraoxonase enzyme activities and significantly lower triglycerid levels suggest that people with this blood group could be in a lower risk group in terms of coronary artery disease. However, these results needs to be confirmed by further comprehensive detailed studies