Osteoporosis Screening: A Review

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Osteoporosis screening,, diagnosis, strategies, opportunistic screening


Increased fragility fracture rates, increased morbidity and mortality, and a tremendous economic burden are all linked to osteoporosis and poor bone health. Osteoporosis, like many other diseases, benefits from early detection and prevention. The imaging and quantification of bone and bone mineral density are crucial in the diagnosis of osteoporosis. Abdominal and thoracic CT provide a valuable opportunity for osteoporosis screening. Despite the significant prevalence and effect of osteoporosis, screening and treatment rates are still low. Apart from abdominal and thoracic CT which provide a valuable opportunity for osteoporosis screening, it is possible to perform fully automatic osteoporosis screening in routine CT scans of the spine, brain, tooth or some other body parts.


Adami, G., Saag, K.G. 2019. Osteoporosis pathophysiology, epidemiology, and screening in rheumatoid arthritis. Current Rheumatology Reports, 21(7): 1-10.

Anderson, P.A., Polly, D.W., Binkley, N. C., Pickhardt, P.J. 2018. Clinical use of opportunistic computed tomography screening for osteoporosis. JBJS, 100(23): 2073-2081.

Barton, D.W., Behrend, C. J., Carmouche, J.J. 2019. Rates of osteoporosis screening and treatment following vertebral fracture. The Spine Journal, 19(3): 411-417.

Chandran, M., Mitchell, P.J., Amphansap, T., Bhadada, S.K., Chadha, M., Chan, D.C., Zhao, Y.L. 2021. Development of the Asia Pacific Consortium on Osteoporosis (APCO) Framework: clinical standards of care for the screening, diagnosis, and management of osteoporosis in the Asia-Pacific region. Osteoporosis International, 32(7): 1249-1275.

Crandall, C.J., Ensrud, K.E. 2020. Osteoporosis screening in younger postmenopausal women. Jama, 323(4): 367-368.

Crandall, C.J., Larson, J., Manson, J.E., Cauley, J.A., LaCroix, A.Z., Wactawski‐Wende, J., Ensrud, K. E. 2019. A comparison of US and Canadian osteoporosis screening and treatment strategies in postmenopausal women. Journal of Bone and Mineral Research, 34(4): 607-615.

Curry, S.J., Krist, A.H., Owens, D.K., Barry, M.J., Caughey, A.B., Davidson, K. W., US Preventive Services Task Force. 2018. Screening for osteoporosis to prevent fractures: US Preventive Services Task Force recommendation statement. Jama, 319(24): 2521-2531.

Fang, Y., Li, W., Chen, X., Chen, K., Kang, H., Yu, P., Li, S. 2021. Opportunistic osteoporosis screening in multi-detector CT images using deep convolutional neural networks. European Radiology, 31(4): 1831-1842.

Fuggle, N.R., Curtis, E.M., Ward, K.A., Harvey, N.C., Dennison, E.M., Cooper, C. 2019. Fracture prediction, imaging and screening in osteoporosis. Nature Reviews Endocrinology, 15(9): 535-547.

Goode, S.C., Wright, T.F., Lynch, C. 2020. Osteoporosis screening and treatment: a collaborative approach. The Journal for Nurse Practitioners, 16(1): 60-63.

International Osteoporosis Foundation. 2013. The Asia-Pacific regional audit. Epidemiology, costs and burden of osteoporosis in 2013. IOF, Nyon, Switzerland

Jain, R.K., Lee, E., Mathai, C., Dako, F., Gogineni, P., Weiner, M.G., Vokes, T. 2020. Using opportunistic screening with abdominal CT to identify osteoporosis and osteopenia in patients with diabetes. Osteoporosis International, 31(11): 2189-2196.

Jang, M., Kim, M., Bae, S.J., Lee, S.H., Koh, J.M., Kim, N. 2022. Opportunistic osteoporosis screening using chest radiographs with deep learning: Development and external validation with a cohort dataset. Journal of Bone and Mineral Research, 37(2): 369-377.

Jang, S., Graffy, P.M., Ziemlewicz, T.J., Lee, S.J., Summers, R.M., Pickhardt, P.J. 2019. Opportunistic osteoporosis screening at routine abdominal and thoracic CT: normative L1 trabecular attenuation values in more than 20 000 adults. Radiology, 291(2): 360-367.

Kadri, A., Binkley, N., Hernando, D., Anderson, P.A. 2022. Opportunistic Use of Lumbar Magnetic Resonance Imaging for Osteoporosis Screening. Osteoporosis International, 33(4): 861-869.

Kwok, T.C., Law, S.W., Leung, E.M., Choy, D. T., Lam, P., Leung, J. C., Cheung, C. L. 2020. Hip fractures are preventable: a proposal for osteoporosis screening and fall prevention in older people. Hong Kong medical journal, 26(3): 227.

Lee, K.S., Jung, S.K., Ryu, J.J., Shin, S.W., Choi, J. 2020. Evaluation of transfer learning with deep convolutional neural networks for screening osteoporosis in dental panoramic radiographs. Journal of clinical medicine, 9(2): 392.

Leslie, W.D., Crandall, C.J. 2019. Population-based osteoporosis primary prevention and screening for quality of care in osteoporosis, current osteoporosis reports. Current Osteoporosis Reports, 17(6): 483-490.

Löffler, M.T., Jacob, A., Scharr, A., Sollmann, N., Burian, E., El Husseini, M., Kirschke, J. S. 2021. Automatic opportunistic osteoporosis screening in routine CT: improved prediction of patients with prevalent vertebral fractures compared to DXA. European radiology, 31(8): 6069-6077.

Mehmet, Y., Başbuğ, A., Kaya, A. E., Çağlar, M., Özkara, A., Sungur, M. A., Ataoğlu, S. 2017. Osteoporoz Sıklığı ve Tarama Programı Başlangıç Yaşının Belirlenmesi: Düzce Üniversitesi Araştırma ve Uygulama Hastanesi Örneklemi. Konuralp Medical Journal/Konuralp Tip Dergisi, 9(1).

Na, M. K., Won, Y.D., Kim, C.H., Kim, J. M., Cheong, J. H., Ryu, J. I., Han, M.H. 2018. Opportunistic osteoporosis screening via the measurement of frontal skull Hounsfield units derived from brain computed tomography images. PLoS One, 13(5): e0197336.

Pan, Y., Shi, D., Wang, H., Chen, T., Cui, D., Cheng, X., Lu, Y. 2020. Automatic opportunistic osteoporosis screening using low-dose chest computed tomography scans obtained for lung cancer screening. European radiology, 30(7): 4107-4116.

Pisu, M., Kopperdahl, D.L., Lewis, C.E., Saag, K.G., Keaveny, T.M. 2019. Cost‐effectiveness of osteoporosis screening using biomechanical computed tomography for patients with a previous abdominal CT. Journal of Bone and Mineral Research, 34(7): 1229-1239.

Roski, F., Hammel, J., Mei, K., Haller, B., Baum, T., Kirschke, J.S., Schwaiger, B.J. 2021. Opportunistic osteoporosis screening: contrast-enhanced dual-layer spectral CT provides accurate measurements of vertebral bone mineral density. European Radiology, 31(5): 3147-3155.

Taguchi, A., Tanaka, R., Kakimoto, N., Morimoto, Y., Arai, Y., Hayashi, T., Asaumi, J. 2021. Clinical guidelines for the application of panoramic radiographs in screening for osteoporosis. Oral radiology, 37(2): 189-208.

Valentinitsch, A., Trebeschi, S., Kaesmacher, J., Lorenz, C., Löffler, M.T., Zimmer, C., Kirschke, J.S. 2019. Opportunistic osteoporosis screening in multi-detector CT images via local classification of textures. Osteoporosis international, 30(6): 1275-1285.

Yang, J., Cosman, F., Stone, P.W., Li, M., Nieves, J.W. 2020. Vertebral fracture assessment (VFA) for osteoporosis screening in US postmenopausal women: is it cost-effective?. Osteoporosis International, 31(12): 2321-2335.

Yılmaz, M. 2022. Ectopic Pregnancy: A Review of Systematic Revıews and Meta-Analysis. Current Approaches in Gynecology and Gyneco-Oncology, 3: 3-20

Zhang, B., Yu, K., Ning, Z., Wang, K., Dong, Y., Liu, X., Zhang, S. 2020. Deep learning of lumbar spine X-ray for osteopenia and osteoporosis screening: a multicenter retrospective cohort study. Bone, 140: 115561.




How to Cite

ÖZBİLGEÇ, S. . (2022). Osteoporosis Screening: A Review. MAS Journal of Applied Sciences, 7(2), 299–306. https://doi.org/10.52520/masjaps.v7i2id173




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