Uterine Smooth Muscle Tumors: A Review
Abstract views: 281
/ 
PDF downloads: 196
DOI:
https://doi.org/10.52520/masjaps.v7i2id172Abstract
Uterine smooth muscle tumors heterogeneous tumors include at least six histologically defined tumor types. Smooth muscle tumors are divided into two categories: benign leiomyomas and malignant leiomyosarcomas. Uterine smooth muscle tumors have also morphological variants that are difficult to interpret and identify as benign or malignant called "smooth muscle tumors of uncertain malignant potential". Immunohistochemistry for progesterone receptor and p53 is useful as a supplement to morphological evaluation of uterine smooth muscle tumors that are causing problems. It might be hard to differentiate between endometrial stromal sarcomas and uterine smooth muscle tumors.
References
Allen, M.M.L., Douds, J.J., Liang, S.X., Desouki, M.M., Parkash, V., Fadare, O. 2015. An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. International journal of clinical and experimental pathology, 8(3): 2795.
Alper, B., Derya, B., Mete, Ç., Ali, Y., Merve, B., Mehmet, Y., Feyza, B. 2015. Coexistence of uterine smooth muscle tumors of uncertain malignant potential (STUMP) and subserosal leiomyoma: A rare cause of postmenopausal bleeding. Türk Jinekolojik Onkoloji Dergisi 2015-(4): 141-144.
Cotrino, I., Carosso, A., Macchi, C., Poma, C. B., Cosma, S., Ribotta, M., Zola, P. 2020. Ultrasound and clinical characteristics of uterine smooth muscle tumors of uncertain malignant potential (STUMPs). European Journal of Obstetrics & Gynecology and Reproductive Biology, 251: 167-172.
Dall’Asta, A., Gizzo, S., Musarò, A., Quaranta, M., Noventa, M., Migliavacca, C., Berretta, R. 2014. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): pathology, follow-up and recurrence. International Journal of Clinical and Experimental Pathology, 7(11): 8136.
Gadducci, A., Zannoni, G. F. 2019. Uterine smooth muscle tumors of unknown malignant potential: a challenging question. Gynecologic Oncology, 154(3): 631-637.
Garcia, N., Bozzini, N., Baiocchi, G., Da Cunha, I.W., Maciel, G.A., Junior, J. M.S., Carvalho, K.C. 2016. May Sonic Hedgehog proteins be markers for malignancy in uterine smooth muscle tumors?. Human Pathology, 50: 43-50.
Garg, K., Rabban, J. 2021. Hereditary leiomyomatosis and renal cell carcinoma syndrome associated uterine smooth muscle tumors: bridging morphology and clinical screening. Genes, Chromosomes and Cancer, 60(3): 210-216.
Hewedi, I.H., Radwan, N.A., Shash, L.S. 2012. Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors. Diagnostic pathology, 7(1): 1-6.
Holzmann, C., Markowski, D.N., Von Leffern, I., Loening, T., Bullerdiek, J. 2015. Patterns of chromosomal abnormalities that can improve diagnosis of uterine smooth muscle tumors. Anticancer Research, 35(12): 6445-6456.
Liegl-Atzwanger, B., Heitzer, E., Flicker, K., Müller, S., Ulz, P., Saglam, O., Moinfar, F. 2016. Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors. Modern pathology, 29(10): 1262-1277.
Makinen, N., Kämpjärvi, K., Frizzell, N., Bützow, R., Vahteristo, P. 2017. Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors. Molecular cancer, 16(1): 1-8.
Miettinen, M. 2014. Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis. Modern Pathology, 27(1): S17-S29.
Rabban, J.T., Chan, E., Mak, J., Zaloudek, C., Garg, K. 2019. Prospective Detection of Germline Mutation of Fumarate Hydratase in Women With
Uterine Smooth Muscle Tumors Using Pathology-based Screening to Trigger Genetic Counseling for Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome. The American Journal of Surgical Pathology, 43(5): 639-655.
Shanes, E.D., Friedman, L.A., Mills, A.M. 2019. PD-L1 Expression and tumor-infiltrating lymphocytes in uterine smooth muscle tumors. The American Journal of Surgical Pathology, 43(6): 792-801.
Suzuki, Y., Wada, S., Nakajima, A., Fukushi, Y., Hayashi, M., Matsuda, T., Fujino, T. 2018. Magnetic resonance imaging grading system for preoperative diagnosis of leiomyomas and uterine smooth muscle tumors. Journal of Minimally Invasive Gynecology, 25(3): 507-513.
Tawfik, O., Rao, D., Nothnick, W.B., Graham, A., Mau, B., Fan, F. 2014. Transgelin, a novel marker of smooth muscle differentiation, effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. International journal of gynecological obstetrical and reproductive medicine research, 1(1): 26.
Uluer, E.T., Inan, S., Ozbilgin, K., Karaca, F., Dicle, N., Sancı, M. 2015. The role of hypoxia related angiogenesis in uterine smooth muscle tumors. Biotechnic & Histochemistry, 90(2): 102-110.
Vilos, G.A., Marks, J., Ettler, H.C., Vilos, A. G., Prefontaine, M., Abu-Rafea, B. 2012. Uterine smooth muscle tumors of uncertain malignant potential: diagnostic challenges and therapeutic dilemmas. Report of 2 cases and review of the literature. Journal of Minimally Invasive Gynecology, 19(3): 288-295.
Yılmaz, M. 2022. Endometriosis: A Review of Systematic Reviews and Meta-Analysis. MAS Journal of Applied Sciences 7(1): 73–80.
Zhang, Q., Ubago, J., Li, L., Guo, H., Liu, Y., Qiang, W., Wei, J.J. 2014. Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma. Cancer, 120(20): 3165-3177.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 The copyright of the published article belongs to its author.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The journal is licensed under a 