Quality of Life And Disability of Patients With Bipolar Disorder According To Treatment Response


Abstract views: 37 / PDF downloads: 21

Authors

DOI:

https://doi.org/10.52520/masjaps.v7i2id171

Keywords:

Bipolar Disorder, treatment response, inadequate response to treatment, life quality, disability

Abstract

Bipolar Disorder (BD) is a lifelong, chronic mental illness with recurrent depressive, manic, hypomanic, or mixed episodes, with euthymic periods between episodes. The inadequate response is defined as the ineffectiveness of the drug from two different groups, despite being used sufficient dose and duration for the specific attack of the disease. BD is also related to impairment in functionality and disability. Most studies have demonstrated marked deterioration of quality of life and disability in patients with BD, even if they are clinically considered euthymic. Our study aims to determine the factors affecting the response to treatment and compare the quality of life and disability in patients with bipolar disorder. Our study included 150 patients with BD between 18-65 years who applied to the Dicle University Faculty of Medicine Psychiatry Clinic. Patients were divided into two groups according to treatment response. Sociodemographic Data Form, Clinical Global Impression Scale (CGI), Sheehan Disability Scale (SDS), World Health Organization Quality of Life Scale (WHOQOL-27) were applied to the participants. Inadequate response group had higher mood episodes, number of hospitalization, inadequate family support, non-adherence to treatment, suicide attempt, psychiatric comorbidity, late-onset treatment, and higher mean CGI-S and SDS subscales scores and lower mean WHOQOL-BREF 27 score. Inadequate response to treatment was associated with worse functionality and disability. Inadequate response related factors such as misdiagnosis, late diagnosis, late treatment, low adherence to treatment, missed psychiatric comorbidity, and inadequate family support should be minimized. Treatment should aim not only to remission symptoms but also aim complete functional recovery and no disability in work, social life, and family life/home responsibilities.

References

Akdemir, A., Türkçapar, M.H., Örsel, S.D., Demirergi, N., Dag, I., Özbay, M.H. 2001. Reliability and validity of the Turkish version of the Hamilton Depression Rating Scale, Comprehensive psychiatry, 42(2): 161-165.

American Psychiatric Association. 2013. Diagnostic and statistical manual of mental disorders (DSM-5). American Psychiatric Publishing.

Belmaker, R.H. 2004. Bipolar disorder. New England Journal of Medicine, 351(5): 476-486.

Carta, M.G., Angst, J. 2005. Epidemiological and clinical aspects of bipolar disorders: controversies or a common need to redefine the aims and methodological aspects of surveys. Clinical Practice and Epidemiology in Mental Health, 1(1): 1-4.

Colom, F., Vieta, E., Martinez-Aran, A., Reinares, M., Goikolea, J. M., Benabarre, A., Corominas, J. 2003. A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Archives of general psychiatry, 60(4): 402-407.

Deckersbach, T., Nierenberg, A.A., McInnis, M.G., Salcedo, S., Bernstein, E.E., Kemp, D.E., Kamali, M. 2016. Baseline disability and poor functioning in bipolar disorder predict worse outcomes: results from the bipolar CHOICE study. The Journal of clinical psychiatry, 77(1): 1753.

Eser, E., Fidaner, H., Fidaner, C., Eser, S. Y., Elbi, H., Göker, E. 1999. WHOQOL-100 ve WHOQOL-BREF'in psikometrik özellikleri. Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi, 7(Suppl 2): 23-40.

Gitlin, M.J., Swendsen, J., Heller, T.L., Hammen, C. 1995. Relapse and impairment in bipolar disorder. The American journal of psychiatry, 152(11): 1635–1640

Gitlin, M. 2006. Treatment-resistant bipolar disorder. Molecular psychiatry, 11(3): 227-240.

Goodwin, F.K., Ghaemi, S.N. 2003. The course of bipolar disorder and the nature of agitated depression. American journal of psychiatry, 160(12): 2077-2079.

Goswami, U., Sharma, A., Khastigir, U., Ferrier, I.N., Young, A.H., Gallagher, P., Moore, P.B. 2006. Neuropsychological dysfunction, soft neurological signs and social disability in euthymic patients with bipolar disorder. The British Journal of Psychiatry, 188(4): 366-373.

Grande, I., Berk, M., Birmaher, B., Vieta, E. 2016. Bipolar disorder. The Lancet, 387(10027): 1561-1572.

Gutiérrez-Rojas, L., Jurado, D., Gurpegui, M. 2011. Factors associated with work, social life and family life disability in bipolar disorder patients. Psychiatry Research, 186(2-3): 254-260.

Guy, W. 1976. Clinical global impressions scale. ECDEU assessment manual for psychopharmacology, 217-222.

Hamilton, M. 1960. A rating scale for depression. J Neurol Neurosurg Psychiatry, 23:56–62.

Karadağ, F., Oral, T., Yalcin, F. A., Erten, E. 2002. Reliability and validity of Turkish translation of young mania rating scale. Turk psikiyatri dergisi= Turkish journal of psychiatry, 13(2): 107-114.

Leboyer, M., Henry, C., Paillere‐Martinot, M.L., Bellivier, F. 2005. Age at onset in bipolar affective disorders: a review. Bipolar disorders, 7(2): 111-118.

Lish, J.D., Dime-Meenan, S., Whybrow, P. C., Price, R.A., Hirschfeld, R.M. 1994. The National Depressive and Manic-depressive Association (DMDA) survey of bipolar members. Journal of affective disorders, 31(4): 281-294.

Martinez‐Aran, A., Vieta, E., Torrent, C., Sanchez‐Moreno, J., Goikolea, J. M., Salamero, M., Ayuso‐Mateos, J. L. 2007. Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar disorders, 9(1‐2): 103-113.

Merikangas, K.R., Akiskal, H.S., Angst, J., Greenberg, P.E., Hirschfeld, R.M., Petukhova, M., Kessler, R.C. 2007. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Archives of general psychiatry, 64(5): 543-552.

Michalak, E.E., Yatham, L.N., Lam, R.W. 2005. Quality of life in bipolar disorder: a review of the literature. Health and quality of life outcomes, 3(1): 1-17.

Morgan, V.A., Mitchell, P.B., Jablensky, A.V. 2005. The epidemiology of bipolar disorder: sociodemographic, disability and service utilization data from the Australian National Study of Low Prevalence (Psychotic) Disorders. Bipolar disorders, 7(4): 326-337.

Murray, C.J., Lopez, A.D. 1997. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. The Lancet, 349(9063):1436-1442.

Özalp, E., Karslıoğlu, E.H. 2015. Tedaviye Dirençli Bipolar Bozukluk. Psikiyatride Güncel Yaklaşımlar, 7(4): 401-418.

Rihmer, Z., Angst, J. 2005. Epidemiology of bipolar disorder. Medical Psychiatry, 32: 21.

Sanchez-Moreno, J., Martinez-Aran, A., Tabarés-Seisdedos, R., Torrent, C., Vieta, E., Ayuso-Mateos, J.L. 2009. Functioning and disability in bipolar disorder: an extensive review. Psychotherapy and psychosomatics, 78(5): 285-297.

Scott, J., Colom, F. 2008. Gaps and limitations of psychological interventions for bipolar disorders. Psychotherapy and psychosomatics, 77(1): 4-11.

Sheehan, D.V., Harnett-Sheehan, K., Raj, B. A. 1996. The measurement of disability. International Clinical Psychopharmacology, 11(Suppl 3): 89–95.

Tohen, M., Frank, E., Bowden, C.L., Colom, F., Ghaemi, S.N., Yatham, L.N., Berk, M. 2009. The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders. Bipolar disorders, 11(5): 453-473.

Tohen, M., Goldberg, J.F., Arrillaga, A.M. G.P., Azorin, J.M., Vieta, E., Hardy-Bayle, M. C., Breier, A. 2003. A 12-week, double-blind comparison of olanzapine vs haloperidol in the treatment of acute mania. Archives of general psychiatry, 60(12): 1218-1226.

Vieta, E., Colom, F., Martinez-Aran, A. 2002. Chronicity, milder forms, and cognitive impairment in bipolar disorder. Bipolar Disorders. WPA Series Evidence and Experience in Psychiatry, Wiley. Chichester, Wiley, 182-184.

Whoqol Group 1998. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychological medicine, 28(3): 551-558.

Whoqol Group 1995. The World Health Organization quality of life assessment (WHOQOL): position paper from the World Health Organization. Social science & medicine, 41(10): 1403-1409.

World Health Organization 2008. World health statistics 2008. World Health Organization.

Young, R.C., Biggs, J.T., Ziegler, V.E., Meyer, D.A. 1978. A rating scale for mania: reliability, validity and sensitivity. The British journal of psychiatry, 133(5): 429-435.

Zarate, C.A., Tohen, M., Land, M., Cavanagh, S. 2000. Functional impairment and cognition in bipolar disorder. Psychiatric Quarterly, 71(4): 309-329.

Downloads

Published

2022-06-07

How to Cite

AVCU, P., ATLI, A., & UYAR, B. . (2022). Quality of Life And Disability of Patients With Bipolar Disorder According To Treatment Response. MAS Journal of Applied Sciences, 7(2), 307–315. https://doi.org/10.52520/masjaps.v7i2id171

Issue

Section

Articles