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An Investigation On The Correlation Between Oxidative Stress And Cognitive Functions In Patients With Euthymic Bipolar Disorder

An Investigation On The Correlation Between Oxidative Stress And Cognitive Functions In Patients With Euthymic Bipolar Disorder

An Investigation On The Correlation Between Oxidative Stress And Cognitive Functions In Patients With Euthymic Bipolar Disorder

 
Author : Süleyman DÖNMEZDİL  Nilüfer Dönmezdil, İbrahim Kaplan, Mahmut Bulut  
Type :
Printing Year : 2021
Number : 6
Page : 135-145
DOI Number: :
Cite : Süleyman DÖNMEZDİL Nilüfer Dönmezdil, İbrahim Kaplan, Mahmut Bulut, (2021). An Investigation On The Correlation Between Oxidative Stress And Cognitive Functions In Patients With Euthymic Bipolar Disorder. MAS Journal of Applied Sciences, 6, p. 135-145. Doi: 10.52520/masjaps.12.
    


Summary

Objective: To investigate the relationship between oxidative stress and cognitive functions in bipolar patients. Methods:The sample of the study consisted of 50 patients and 50 healthy volunteers who applied to the Department of Psychiatry. Global Clinical Monitoring Scale (GCMS), Hamilton Depression Scale (HAM-D), Young Mania Rating Scale (YMRS), serial step learning test (SDLT), Stroop Test Basic Sciences Research Group Form (ST-TBAG), Preliminary Evaluation Battery ( ST-TBAG) FAB) was applied to healthy volunteers with a socio-demographic data form. In addition, venous blood was collected and Total Oxidant Level (TOL) and Total Antioxidant Level (TAL) were measured. Results:TOL and OSI levels were found to be significant between the patient groups and the control group in the tests and measurements performed (p <0.01). The stroop test applied to both the patient and the control group was statistically significant in terms of Frontal Assessment Battery (FAB) and number series learning test (p <0.05). In addition, there was a statistically significant relationship between FAB and TOL (p: 0.012 r: -0.353) and OSI (p: 0.014 r: -0.346) applied to patients. Conclusion: As a result, there was a significant correlation with oxidative parameters and disorder in cognitive function tests compared to the control group.



Keywords
Bipolar Disorder; Cognitive Functions; Oxidative Parameters

Abstract

Objective: To investigate the relationship between oxidative stress and cognitive functions in bipolar patients. Methods:The sample of the study consisted of 50 patients and 50 healthy volunteers who applied to the Department of Psychiatry. Global Clinical Monitoring Scale (GCMS), Hamilton Depression Scale (HAM-D), Young Mania Rating Scale (YMRS), serial step learning test (SDLT), Stroop Test Basic Sciences Research Group Form (ST-TBAG), Preliminary Evaluation Battery ( ST-TBAG) FAB) was applied to healthy volunteers with a socio-demographic data form. In addition, venous blood was collected and Total Oxidant Level (TOL) and Total Antioxidant Level (TAL) were measured. Results:TOL and OSI levels were found to be significant between the patient groups and the control group in the tests and measurements performed (p <0.01). The stroop test applied to both the patient and the control group was statistically significant in terms of Frontal Assessment Battery (FAB) and number series learning test (p <0.05). In addition, there was a statistically significant relationship between FAB and TOL (p: 0.012 r: -0.353) and OSI (p: 0.014 r: -0.346) applied to patients. Conclusion: As a result, there was a significant correlation with oxidative parameters and disorder in cognitive function tests compared to the control group.



Keywords
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